Xue-Jun Song, MD, PhD

Parker Research Institute

Xue-Jun Song, MD, PhD

Dr. Song received his MD (1986) from Xuzhou Medical College and PhD (1995) in neurobiology from Chinese Academy of Sciences Shanghai Brain Research Institute. Dr. Song, as a postdoctoral fellow, did his research in the department of anesthesiology and neurobiology at Yale University School of Medicine from 1995-1998, and then as an instructor in the department of integrative biology, pharmacology, and physiology at The University of Texas Medical Center at Houston from 1998-1999. Dr. Song joined Parker in 1999 as a senior scientist. He was later promoted to associate professor and is currently full professor.

Dr. Song has established a laboratory at Parker University focusing on neurophysiological studies of chronic pain and nerve injury. His research is directed toward elucidating cellular and molecular mechanisms of pain and hyperalgesia using the animal models of chronic pain produced by inflammation or injuries to the sensory neurons and the spinal cord, and exploring therapeutic countermeasures. Another major project is to investigate the effects and neural mechanisms of treatment of chiropractic on chronic pain. Dr. Song’s research has provided and will continue to provide sound scientific evidence to support the chiropractic profession and Parker University.

Education and Professional Experiences

1981-1986 M.D., Xuzhou Medical College, Xuzhou, China
1990-1995 Ph.D., Chinese Academy of Sciences Shanghai Brain Research Institute (today’s Institute of Neuroscience), Shanghai, China
1995-1998 Postdoctoral follow, Yale University School of Medicine, New Haven, CT
1998-1999 Instructor/Research Assistant professor, The University of Texas Medical Center, Houston, TX
1999-2000 Senior Scientist/Assistant professor, Head of Laboratory of Neurobiology, Parker Research Institute, Dallas, TX
2000-2003 Senior Scientist, Associate Professor, Director of Section of Basic Science Research and Associate Director of Parker Research Institute, Dallas, TX
November 2003- Professor, Senior Scientist, Director of Section of Basic Science Research and Associate Director of Parker Research Institute, Dallas, TX

Research Interests

Dr. Song’s current research is directed toward demonstrating 1) functional implications and cellular and molecular mechanisms of chronic pain after nerve injury, spinal cord trauma, inflammation or diseases such as bone cancer, diabetics, etc., and the therapeutic countermeasures; 2) mechanisms of opioid actions and clinical use of morphine in treating chronic pain; 3) analgesic effects and neural protection of B vitamins; and 4) treatment effects and neurophysiologic mechanisms underlying spinal manipulation on the back pain and spinal injury or inflammation in rodents and human beings.

Selected Academic Awards and Research Funds

1993 Third National Excellent Academic Research Award for Chinese Young Physiologists (top two) – Chinese Association of Physiological Sciences and Xijun Zhang Foundation
1994 Presidential Award of Chinese Academy of Sciences– President of Chinese Academy of Sciences
1995 Extraordinary Young Scientist Award – Chinese Academy of Sciences Shanghai Branch and the Foundation for Extraordinary Ability Scientists
1999 Natural Science Award (Second place) – Chinese Academy of Sciences
1999 Science and Technology Advancement Award (Third place) – Jiangsu Province Government
1999 Starting funds for chronic pain and chiropractic research – Parker University Research Foundation, US
2001 Parker University Research Foundation
2004 Research fund, National Institute of Health, US (collaboration)
2005 Parker University Research Foundation
2005 The Scott Haledeman Award – World Federation of Chiropractic (WFC) Research Council and Foundation of Chiropractic Education and Research.
2005 Award of “Researcher of the Year” – Activator Methods International LTD, the Unites States
2006 Outstanding Young Scientist Award (Type B), National Natural Science Foundation of China (NSFC)
2006 Science and Technology Advancement Award (First place) – Ministry of Education, China
2006 Activator Research Fund – National Institute of Chiropractic Research, US
2007 Faculty 1000 Biology – The expert guide to the most important advances in biology – American Physiological Society / Journal of Neurophysiology.
2007 Outstanding Faculty Award – Parker University College of Chiropractic
2007 Core Products Pain Research Funds, US
2008 Research fund, National Institute of Health
2008 Parker University Research Foundation
2009 Core Products Pain Research Funds, US
2009 Research fund, National Institute of Health (collaboration)
2012 Parker University Research Foundation
2012 Research fund, NSFC
2012 Australia Spinal Research Foundation, Australia
2013 Research fund, Department of Defense, US (collaboration)
2014 Research fund, International Collaboration, NSFC.

Current Lab Members

Xue-Jun Song, MD, PhD, Professor
Maria Dominguez, Research Coordinator
Zh-Jiang Huang, PhD, Research scientist
Yan-Kai Zhang, PhD, Research scientist
Duanduan He, MD, PhD, Research Scientist/Lecturer
Xue-Ting Deng, Research Scientist
Ni Xu, MD, PhD student
Qing-Ying Liu, MD, PhD student
Ming-Zheng Wu, MD, PhD student
Yuan Zong, MD, PhD student
Ping-Chuan Ma, MD, PhD student
Hui Ma, MD, MS, PhD student

Research Collaboration Records

Edgar T. Walters, PhD, Professor, The University of Texas Medical Center, Houston, TX
Robert H. LaMotte, PhD, Professor, Yale University School of Medicine, New Haven, CT
Yimin Zou, PhD, Professor, University of Chicago, Chicago, IL
Yiming Zeng, MD, Yong-Ping Wu, MD, Professors, Xuzhou Medical College, Xuzhou
Qingquan Lian, MD, PhD, Hong Cao, MD, Professors, Wenzhou Medical College, Wenzhou
Lize Xiong, MD, PhD, Professor, President, Xijing Hospital, The Fourth Military Medical University, Xi’an
San-Ju Hu, MD, Professor, Neurosci Res Inst, The Fourth Military Medical University, Xi’an
Mark Henkemayer, PhD, Professor, University of Texas Southwestern Medical Center at Dallas, TX
Jisheng Han, MD, Professor and Member of Chinese Academy of Sciences, Peking University Health Science Center, Beijing.

Selected publications after joining Parker University (since 1999)

Zhang YK, Huang ZJ, Liu S, Liu YP, Song AA, Song XJ. WNT signaling underlies the pathogenesis of neuropathic pain in rodents. Journal of Clinical Investigation 2013; 123(5):2268-86.
—Highlight by Nature Review Drug Discovery, 2013, 2014; Harvard PainResearchForum 2013, Faculty 1000 Premium, 2013, etc.

Liu S, Liu YP, Song WB, Song XJ. EphrinB-EphB receptor signaling contributes to bone cancer pain via Toll-like receptor and proinflammatory cytokines in rat spinal cord. Pain 2013;154(12):2823-35.

Yu CZ, Liu YP, Liu S, Yan M, Hu SJ, Song XJ. Systematic administration of B vitamins attenuates neuropathic hyperalgesia and reduces spinal neuron injury following temporary spinal cord ischaemia in rats. Eur J Pain 2014; 18(1):76-85.

Huang ZJ, Li HC, Cowan AA, Zhang YK, Song XJ. Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2. Pain 2012; 27, 153:1426-1437.

Gu N, Niu JY, Liu WT, Sun YY, Liu S, Lv Y, Dong HL, Song XJ, Xiong LZ. Hyperbaric oxygen treatment attenuates neuropathic hyperalgesia in rats and idiopathic trigeminal neuralgia in patients. Eur J Pain 2012;16(8):1094-105.
—Highlighted by the journal with editor focus.

Song Y, Li HM, Xie RG, Yue ZF, Song XJ, Hu SJ, Xing JL. Evoked bursting in injured Aβ-dorsal root ganglion neurons: a mechanism underlying tactile allodynia. Pain 2012; 153(3):657-65.

Sun W, Miao B, Wang XC, Duan JH, Wang WT, Kuang F, Xie RG, Xing JL, Xu H, Song XJ, Luo C, Hu SJ. Reduced conduction failure of the main axon of polymodal nociceptive C-fibers contributes to painful diabetic neuropathy in rats. Brain 2012; 135(Pt 2):359-75.

Wu XF, Liu WT, Liu YP, Huang ZJ, Zhang YK, Song XJ. Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord. Pain 2011,152:2605-2613.

Liu S, Liu WT, Liu YP, Dong HL, Henkemeyer M, Xiong LZ, Song XJ. Blocking EphB1 Receptor Forward Signaling in Spinal Cord Relieves Bone Cancer Pain and Rescues Analgesic Effect of Morphine Treatment in Rodents. Cancer Research 2011; 71(13): 4392-402.
—Highlighted by American Cancer Society and local media.

Huang ZJ, Hsu, E, Rosner A, Rupert RL, Song XJ: Topical application of compound Ibuprofen suppresses pain by inhibiting sensory neuron hyperexcitability and neuroinflammation in a rat model of intervertebral foramen inflammation. Journal of Pain. 2011; 12(1):141-52.

Liu WT, Han Y, Liu YP, Song AA, Barnes B, Song XJ. Spinal matrix metalloproteinase-9 contributes to physical dependence on morphine in mice. The Journal of Neuroscience 2010, 30(22):7613-23.

Liu WT, Li HC, Song XS, Huang ZJ, Song XJ. EphB Receptor Signaling in Mouse Spinal Cord Contributes to Physical Dependence on Morphine. FASEB Journal 2009 Jan; 23(1):90-98.

Song XS, Huang ZJ, Song XJ. Thiamine may suppress thermal hyperalgesia by inhibiting hyperexcitability and regulating altered sodium channel of the injured dorsal root ganglion neurons in rats. Anesthesiology 2009; 110:387-400.

Liu WT, Han Y, Li HC, Adams B, Zheng JH, Wu YP, Henkemeyer M, Song XJ. An in vivo mouse model of long-term potentiation at synapses between primary afferent C-fibers and spinal dorsal horn neurons: essential role of EphB1 receptor. Molecular Pain, 2009 June; 5:29, 1-13.

Han Y, Song XS, Liu WT, Henkemeyer M, Song XJ. Targeted Mutation of EphB1 Receptor Prevents Development of Neuropathic Hyperalgesia and Physical Dependence on Morphine in Mice. Molecular Pain 2008;4(1):60-66.

Song XJ, Cao JL, Li HC, Song XS, Xiong LZ. Upregulation and redistribution of ephrin1B-EphB1 receptor signaling in dorsal root ganglion and spinal dorsal horn after nerve injury and dorsal rhizotomy. European Journal of Pain 2008;11, 12(8): 1031-1039. Huang ZJ and Song XJ: Differential alteration of sodium currents in nociceptive dorsal root ganglion neurons following injuries to the somata and peripheral branches of axons. Molecular Pain 2008; 4:20-26.

Song XJ, Zheng JH, Cao JL, Li HC, Liu WT, Song XS Huang ZJ: EphrinB-EphB receptor signaling contributes to neuropathic pain by regulating neural excitability and spinal plasticity in rats. Pain 2008,139:168-180.

Cao JL, Ruan JP, Ling DY, Guan XH, Bao Q, Yuan Y, Zhang LC, Song XJ, Zeng YM. Activation of peripheral ephrinBs/EphBs signaling induces hyperalgesia through a MAPKs-mediated mechanism in mice. Pain 2008, 139: 617-631

Song XJ. Pain Mechanisms and Treatment. In A. Fuhr: The Activator Method, 2nd ed. Mosby, Elsevier, St Louis, Missouri. 2008, p.43-64 Zheng JH, Walters ET, and Song XJ: Dissociation of dorsal root ganglion neurons induces hyperexcitability that is maintained by increases responsiveness to cAMP and cGMP. Journal of Neurophysiology 2007;97:15-25. —Highlighted by the Journal with Editorial Focus in 2007; 97:1-2

Song XJ, Wang ZB, Gan Q, and Walters ET: cAMP and cGMP Pathways contribute to expression of hyperalgesia and sensory neuron hyperexcitability following dorsal root ganglion compression in the rat. Journal of Neurophysiology 2006; 95:479-492. Song XJ, Gan Q, Cao JL, Wang ZB, Rupert RL: Spinal manipulation reduces pain and hyperalgesia produced by lumbar intervertebral foramen inflammation in the rat. Journal of Manipulative Physiological Therapy 2006; 29:1-9.

Wang ZB, Gan Q, Rupert RL, and Song XJ: Thiamine, pyridoxine, cyanocobalamin and their combination inhibit thermal but not mechanical hyperalgesia in rats with primary sensory neuron injury. Pain 2005;114(1-2):266-77.
—Highlighted by the American Physiological Society and dozens of media including NBC, CBS, etc. and magazines such as Psychology Today, Shape, etc.

Zheng JH, Song XJ: Aβ-Afferents Activate NK-1 Receptor in Dorsal Horn Neurons after Nerve Injury. NeuroReport 2005;16(7):715-9 Liu YB, Shi J, Lu CC, Wang ZB, Song XJ, Zou YM: Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract. Nature Neuroscience 2005; 8(9):1151-9.
—Highlighted by the journal with Editor’s Focus and Media.

Song XJ and Rupert RL (chapter in a Textbook): Central projections of spinal receptors. In Haldeman S: Principle and Practice of Chiropractic, 3rd ed, McGraw-Hill, New York. 2004; P. 269-288.

Song, XJ, Vizcarra C, Xu DS, Rupert RL, Wong ZN: Hyperalgesia and neural excitability following injuries to the peripheral and central branches of axon and somata of dorsal root ganglion neurons. Journal of Neurophysiology 2003; 89:2185-2193. Song XJ, Zhang JM and LaMotte RH: Somata of nerve-injured sensory neurons exhibit enhanced responses to inflammatory mediators. Pain 2003;104(3):701-709.

Song XJ, Xu DS, Vizcarra C, Rupert RL: Onset and recovery of hyperalgesia and hyperexcitability of sensory neurons following intervertebral foramen volume reduction and restoration. Journal of Manipulative Physiological Therapy. 2003; 26(7):426-436. Pickar JG, Polus BI, …Song XJ, Vernon H (equal contribution): Neuroscience in the Chiropractic Curriculum. Journal of Neuromusculoskeletal System, 2001; 9(3): 77-81.

Hu SJ, Song XJ, and LaMotte RH: Protein kinase A mediates the generation of ectopic spontaneous activity in chronically compressed dorsal root ganglion. Pain, 2001; 94(1):39-46.

Zhang JM, Song XJ and LaMotte RH: Chronic mechanical compression of the dorsal root ganglion enhances neuronal excitability. J. Neurophysiol. 1999; 82(6): 3359-3366.

Song XJ, Hu SJ, Greenquist K and LaMotte RH: Mechanical and thermal cutaneous hyperalgesia and ectopic neuronal discharge in rats with chronically compressed dorsal root ganglia. Journal of Neurophysiology 1999; 82(6): 3347-3358.